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Biochemistry: An Integrative Approach, 1st Edition, International Adaptation

확대보기
지은이 :  John T. Tansey
발행일 :  2022 년
ISBN :  9781119820802
:  0 원
페이지 :  1008 페이지
:  1
출판사 :  Wiley

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도서소개
Biochemistry, An Integrative Approach with Expanded Topics, offers a unique approach to the subject, emphasizing problem-solving and critical thinking over rote memorization. It integrates subjects of interest to undergraduates majoring in, biochemistry, life science, and beyond while preserving a chemical perspective. The book covers DNA, RNA, gene regulation, synthetic proteins, omics, plant biochemistry, and more. Key concepts such as metabolism, are introduced and then revisited and cross-referenced throughout the text to establish pattern recognition and help students commit their new knowledge to long-term memory. Emphasis is also laid on problem-solving and reasoning skills essential to life sciences, including data analysis and research assessment. This edition of the book aims to empower students studying a range of disciplines to develop a lasting foundation in biochemistry and metabolism.

  • Extensively updated concept check problems, and end-of-chapter problems. 
  • New sections supplemented on ATP-the free energy carrier in Chapter 1, Nucleic acids are the genetic materials in Chapter 2, Amino acid sequencing techniques and Protein sequencing techniques in Chapter 3, Nomenclature of enzymes in Chapter 4, Electrical properties of membranes in Chapter 5, Identification of monosaccharides using different reagents and coordinated regulation of gluconeogenesis and glycolysis through hormones in Chapter 6, Other modes of fatty acid oxidation in Chapter 9, Biosynthesis of amino acids in Chapter 11, and Electron microscopy for next-generation macromolecular determination in Chapter 18. 
  • Chapters on Protein I: Structure has been merged with chapter on Protein Purification. Similarly, chapter on Protein II Enzymes and chapter on Allosterism have been merged. 
  • Gives four guiding themes with pertinent examples that ground the concepts in the chapter with the broader themes used throughout the book: Evolution; Structure and Function; Information Flow, Exchange, and Storage; and Pathways and Transformations of Matter and Energy. 
  • Contains three types of boxed features: Medical Biochemistry, Biochemistry, and Societal and Ethical Biochemistry. 
  • Comprises end of chapter problems that use research and biomedical examples to reinforce key concepts in the chapter. 
저자 및 역자 소개
차례

1 The Chemical Foundations of Biochemistry

Chemistry in Context

1.1 General Chemical Principles

1.2 Fundamental Concepts of Organic Chemistry

1.3 The Chemistry of Water

 

2 Nucleic Acids

Nucleic Acids in Context

Nucleic acids are the Genetic Materials

2.1 Nucleic Acids Have Distinct Structures

2.2 Nucleic Acids Have Many Cellular Functions

2.3 The Manipulation of Nucleic Acids Has Transformed Biochemistry

 

3 Proteins I: An Introduction to Protein Structure, Function, and its Purification

Proteins in Context

3.1 Amino Acid Chemistry

3.2 Proteins Are Polymers of Amino Acids

3.3 Proteins Are Molecules of Defined Shape and Structure

3.4 Examples of Protein Structures and Functions

3.5 Protein Purification Basics

3.6 Size-Exclusion Chromatography

3.7 Affinity Chromatography

 

4 Proteins II: Enzymes

Enzymes in Context

4.1 Introduction to Enzymes

4.2 Enzymes Increase Reaction Rate

4.3 The Mechanism of an Enzyme Can Be Deduced from Structural, Kinetic, and Spectral Data

4.4 Examples of Enzyme Regulation

4.5 Allosterism and Cooperativity

4.6 Hemoglobin

4.7 ReceptorLigand Interactions

 

5 Membranes and an Introduction to Signal Transduction

Biochemistry in Context

5.1 Membrane Structure and Function

5.2 Signal Transduction

 

6 Carbohydrates I: Mono- and Disaccharides, Glycolysis, Gluconeogenesis, and the Fates of Pyruvate

Carbohydrates in Context

6.1 Properties, Nomenclature, and Biological Functions of Monosaccharides

6.2 Properties, Nomenclature, and Biological Functions of Complex Carbohydrates

6.3 Glycolysis and an Introduction to Metabolic Pathways

6.4 Gluconeogenesis

6.5 The Fates of Pyruvate

 

7 The Common Catabolic Pathway: Citric Acid Cycle, the Electron Transport Chain, and ATP Biosynthesis

Electron Transport in Context

7.1 The Citric Acid Cycle

7.2 The Electron Transport Chain

7.3 ATP Biosynthesis

 

8 Carbohydrates II: Glycogen Metabolism, the Pentose Phosphate Pathway, Glycoconjugates, and Extracellular Matrices

Polysaccharides in Context

8.1 Glycogen Metabolism

8.2 The Pentose Phosphate Pathway

8.3 Carbohydrates in Glycoconjugates

8.4 Extracellular Matrices and Biofilms

 

9 Lipids I: Fatty Acids, Steroids, and Eicosanoids; Beta-Oxidation and Fatty Acid Biosynthesis

Lipids in Context

9.1 Properties, Nomenclature, and Biological Functions of Lipid Molecules

9.2 Fatty Acid Biosynthesis

9.3 Fatty Acid Catabolism

9.4 Ketone Body Metabolism

9.5 Steroid Metabolism

9.6 Eicosanoid and Endocannabinoid Metabolism

 

10 Lipids II: Metabolism and Transport of Complex Lipids

Complex Lipids in Context

10.1 Phospholipid Metabolism

10.2 Digestion of Triacylglycerols

10.3 Transport of Lipids in the Circulation

10.4 Entry of Lipids into the Cell

10.5 Neutral Lipid Biosynthesis

10.6 Lipid Storage Droplets, Fat Storage, and Mobilization

10.7 Lipid Rafts as a Biochemical Entity

 

11 Amino Acid and Amine Metabolism

Amine Metabolism in Context

11.1 Digestion of Proteins

11.2 Amino Acid Deamination and Transamination

11.3 The Urea Cycle

11.4 Metabolism of Amino Acid Carbon Skeleton

11.5 The Detoxification of Other Amines and Xenobiotics

11.6 The Biochemistry of Renal Function

 

12 Regulation and Integration of Metabolism

Metabolism in Context

12.1 A Review of the Pathways and Crossroads of Metabolism

12.2 Organ Specialization and Metabolic States

12.3 Communication between Organs

12.4 Metabolic Disease

 

13 Nucleotide and Deoxynucleotide Metabolism

Nucleotides and Deoxynucleotides in Context

13.1 Purine Biosynthesis

13.2 Pyrimidine Biosynthesis

13.3 Deoxyribonucleotide Biosynthesis

13.4 Catabolism of Nucleotides

 

14 DNA Replication, Damage, and Repair

DNA in Context

14.1 Challenges of DNA Replication

14.2 DNA Replication in Prokaryotes

14.3 DNA Replication in Eukaryotes

14.4 DNA Damage and Repair

14.5 Homologous Recombination

 

15 RNA Synthesis and Processing

RNA Synthesis in Context

15.1 Transcription: RNA Synthesis

15.2 Processing of Nascent Eukaryotic RNA Messages

15.3 RNA Export from the Nucleus

 

16 Protein Biosynthesis

Protein Synthesis in Context

16.1 The Genetic Code

16.2 Machinery Involved in in Protein Biosynthesis

16.3 Mechanism of Protein Biosynthesis

 

17 Control and Regulation of Gene Expression

Gene Regulation in Context

17.1 DNA--Protein Interactions

17.2 Regulation of Gene Expression in Prokaryotes

17.3 Regulation of Gene Expression in Eukaryotes

 

18 Determination of Macromolecular Structure

Macromolecular Structure in Context

18.1 An Introduction to Structure Determination

18.2 Electron MicroscopyTypes and Advantages

18.3 X-Ray Diffraction and Neutron Scattering

18.4 Nuclear Magnetic Resonance

 

19 Protein Production, Engineering and Folding

Protein Production, Engineering and Folding in Context

19.1 Protein Production

19.2 Protein Engineering

19.3 Protein Folding

 

20 Bioinformatics and Omics

Bioinformatics in Context

20.1 Introduction to Bioinformatics

20.2 Generating Bioinformatic Data

20.3 Analyzing Bioinformatic Data

 

21 Signal Transduction

Cell Signaling in Context

21.1 A Review of Signal Transduction

21.2 An Overview of Regulation of Signal Transduction

21.3 Six New Signal Transduction Pathways

 

22 Protein Trafficking

Protein Trafficking in Context

22.1 Molecular Aspects of Protein Trafficking

22.2 Molecular Motor Proteins

22.3 Vesicular Fusion

 

23 Photosynthesis and Nitrogen Fixation

Photosynthesis and Nitrogen Fixation in Context

23.1 Photosynthesis

23.2 Nitrogen Fixation

 

Techniques

Solutions

Glossary

Index